2020-Present
  1.  H. Seo, S. Capece, J. Hill, J. Otten, E.T. Papoutsakis, Butyrate as a growth factor of Clostridium acetobutylicum, Metab. Eng. (2024)

  2. H. Seo, G. Castro, C.T. Trinh, Engineering a synthetic Escherichia coli coculture for compartmentalized de novo biosynthesis of isobutyl butyrate from mixed sugars, ACS Synth. Biol., (2023), 13 (1), 259-268

  3. H. Seo, P. Singh, C.E. Wyman, C.M. Cai, C.T. Trinh, Rewiring metabolism of Clostridium thermocellum for consolidated bioprocessing of lignocellulosic biomass poplar to produce short-chain esters, Bioresour. Technol., (2023), 384:29263

  4. H. Seo, R.J. Giannone, Y.H. Yang, C.T. Trinh, Proteome reallocation enables the selective de novo biosynthesis of non-linear, branched-chain acetate esters, Metab. Eng., (2022), 73:38-49.

  5. J.W. Lee, H. Seo, C. Young, C.T. Trinh, Probing Specificities of Alcohol Acyltransferases for Designer Ester Biosynthesis with a High-Throughput Microbial Screening Platform, Biotechnol. Bioeng., (2021), 118:4655–4667

  6. H. Seo, J.W. Lee, R.J. Giannone, N.J. Dunlap, C.T. Trinh, Engineering promiscuity of chloramphenicol acetyltransferase for microbial designer ester biosynthesis, Metab. Eng., (2021), 66:179-190

  7. S. Poudel, A. Cope, K. O’Dell, A. M. Guss, H. Seo, C. T. Trinh, R.L. Hettich, Identification and characterization of proteins of unknown function (PUFs) in Clostridium thermocellum DSM 1313 strains as potential genetic engineering targets, Biotechnol. Biofuels, (2021), 14:116

  8. H. Seo, P.N. Nicely, C.T. Trinh, Endogenous carbohydrate esterases of Clostridium thermocellum are identified and disrupted for enhanced isobutyl acetate production from cellulose, Biotechnol. Bioeng., (2020), 117 (7), 2223-2236 (Journal cover featured)

2010-2019

  1. H. Seo, J.W. Lee, S. Garcia, C.T. Trinh, Single mutation at a highly conserved region of chloramphenicol acetyltransferase enables isobutyl acetate production directly from cellulose by Clostridium thermocellum at elevated temperatures, Biotechnol. Biofuels, (2019), 12:245

  2. J. Kim, H.M. Seo, S. K. Bhatia, H.S. Song, J.H. Kim, J.M. Jeon, K.Y. Choi, W. Kim, J.J. Yoon, Y.G. Kim, Y.H. Yang, Production of itaconate by whole-cell bioconversion of citrate mediated by expression of multiple cis-aconitate decarboxylase (cadA) genes in Escherichia coli, Sci. Rep., (2017), 7: 39768.

  3. H.M. Seo, J.H. Kim, G. Sathiyanarayanan, S. K. Bhatia, H.S. Song, J. Kim, J.M. Jeon, J.J. Yoon, Y.G. Kim, K. Park, Y.H. Yang. Development of a continuous L-lysine bioconversion system for cadaverine production, J Ind Eng Chemistry, (2017), 46: 44-48

  4. H.M. Seo, J.H. Kim, J.M. Jeon, H.S. Song, S.K. Bhatia, G. Sathiyanarayanan, K. Park, S.H. Lee, Y.H. Yang, In situ immobilization of CadA on biopolymer by fusion to phasin protein, Process Biochem. (2016), 51 (10), 1413-1419

  5. S.K. Bhatia,Y.H. Kim, H.J. Kim, H.M. Seo, J.H. Kim, H.S. Song, G. Sathiyanarayanan, S.H. Park, K. Park, Y.H. Yang. Biotransformation of lysine into cadaverine using barium alginate-immobilized Escherichia coli overexpressing CadA, Bioprocess Biosyst Eng.,(2015) Dec;38(12):2315-22. doi: 10.1007/s00449-015-1465-9

  6. D.H. Yi, G. Sathiyanarayanan, H.M. Seo, J.H. Kim, S.K. Bathia, Y.G. Kim, S.H. Park, J.Y. Jung, Y.K. Lee, Y.H. Yang, Sensitive change of iso-branched fatty acid (iso-15:0) in Bacillus pumilus PAMC 23174 in response to environmental changes. Bioprocess Biosyst Eng., (2015), 39 (1), 159-167

  7. S.K. Bhatia, D.H. Yi, Y.H. Kim, H.J. Kim, H.M. Seo, J.H. Lee, J.H. Kim, J.M. Jeon, K.S. Jang, Y.G. Kim, Y.H. Yang. Development of semi-synthetic microbial consortia of Streptomyces coelicolor for increased production of biodiesel (fatty acid methyl esters), Fuel, (2015), 159: 189-196 

  8. Y.H. Kim, H.J. Kim, J.H. Shin, S.K. Bhatia, H.M. Seo, Y.G. Kim, Y.K. Lee, Y.H. Yang, K.M. Park., Application of diethyl ethoxymethylenemalonate (DEEMM) derivatization for monitoring of lysine decarboxylase activity, J. Mol. Catal. B: Enzym., (2015), 115:151-154

  9. H.S. Song, H.M. Seo, J.M. Jeon, Y.M Moon, J.W. Hong, Y.G. Hong, S. K. Bhatia, J. Ahn, H. Lee, W. Kim, Y.C. Park, K.Y. Choi, Y.G. Kim, Y.H. Yang, Enhanced isobutanol production from acetate by combinatorial overexpression of acetyl‐CoA synthetase and anaplerotic enzymes in engineered Escherichia coli, Biotechnol. Bioeng., (2018), 115:1971–1978.

  10. J.M. Jeon, H.J. Kim, S. K. Bhatia, C. Sung, H.M. Seo, J.H. Kim, H.Y. Park, D. Lee, C. J. Brigham, Y.H. Yang, Application of acetyl-CoA acetyltransferase (AtoAD) in Escherichia coli to increase 3-hydroxyvalerate fraction in poly(3-hydroxybutyrate-co-3-hydroxyvalerate), Bioprocess Biosyst Eng., (2017) 40:781–789

  11. H.M. Seo, J.M. Jeon, J.H. Lee, H.S. Song, H.B. Joo, S.H. Park, K.Y. Choi, Y.H. Kim, K. Park, J. Ahn, H. Lee, Y.H. Yang. Combinatorial application of two aldehyde oxidoreductases on isobutanol production in the presence of furfural, J Ind Microbiol Biotechnol, (2016), 43: 37.

  12. S.K. Bhatia,Y.H. Kim, H.J. Kim, H.M. Seo, J.H. Kim, H.S. Song, G. Sathiyanarayanan, S.H. Park, K. Park, Y.H. Yang. Biotransformation of lysine into cadaverine using barium alginate-immobilized Escherichia coli overexpressing CadA, Bioprocess Biosyst Eng.,(2015) Dec;38(12):2315-22. doi: 10.1007/s00449-015-1465-9

CAT paper

Engineering promiscuity of chloramphenicol acetyltransferase for microbial designer ester biosynthesis

Repurposing an antibiotic resistance protein for sustainable bioester production.
Butyrate

Butyrate as a growth factor of Clostridium acetobutylicum

Identifying the importance of butyrate to cellular programs of a representative butyrate-forming Clostridium.
CBP ester

Rewiring metabolism of Clostridium thermocellum for consolidated bioprocessing of lignocellulosic biomass poplar to produce shor

First-ever demonstration of direct conversion of poplar lignocellulose into volatile esters at elevated temperatures.
E.coli coculture

Engineering a synthetic Escherichia coli coculture for compartmentalized de novo biosynthesis of isobutyl butyrate from mixed su

Division of labor to implement more complicated tasks: mixed substrate utilization and metabolically difficult medium chain ester biosynthesis.